Tampa General Hospital and Casa Ybor Reveal Plans for New Hospital, Clinic in Historic Ybor City

Part of Darryl Shaw’s Broader Vision to Revitalize Culture-Rich Neighborhood, Tampa General’s Proposal for Ybor Will Increase Access to World-Class Care, Create Jobs and Attract Investment

TAMPA, FL (October 30, 2025) - Tampa General Hospital and local developer Darryl Shaw revealed plans to build a hospital, clinic and medical office building in east Ybor City during a meeting of the Tampa City Council Thursday evening.

“The transformation underway in Ybor City is bringing new life, businesses, jobs and opportunity back to this historic Tampa landmark,” said Shaw, chief executive officer of Casa Ybor, the driving force behind the neighborhood’s revitalization. “Expanding Tampa General’s footprint in Ybor will offer the new residents, professionals and visitors we’re attracting to Ybor convenient access to exceptional health care.”

“Ybor City and Tampa General Hospital are both great landmarks in Tampa history,” said John Couris, president and CEO of Tampa General Hospital. “As Ybor continues to evolve, we’re proud to expand Tampa General’s presence and be a part of it. Our plans for a new hospital and clinical space are designed to meet the growing demand for world-class care, deeply rooted in academic excellence and research. This marks another milestone in our journey to strengthen the Tampa Medical & Research District and build a thriving and inclusive health care ecosystem in the city of Tampa.”

Tampa City Council tonight considered and approved a Comprehensive Plan amendment for parcels owned by Shaw in the eastern portion of Ybor City. The amendment opens up the potential for residential and commercial mixed-use development rather than solely industrial use. During tonight’s presentation for this separate development, Shaw briefed members of the Tampa City Council on Tampa General’s intent to purchase approximately 10 acres with the option to acquire an additional 6.45 acres in Ybor City, located west of Lee Roy Selmon Expressway Connector between East Adamo Drive and East 4^th Avenue.

Tampa General plans to construct a hospital and clinical offices, which would provide primary care and urgent care services, offering area residents greater access to world-class care from one of the nation’s leading academic health systems. Scenarios for the two-block area consider the possibility of office space and ground-level retail space along with the potential for hotel and residential units.

“At Tampa General, we know that patients value convenience and accessibility when it comes to health care,” said Adam Smith, executive vice president and chief ambulatory care officer at Tampa General Hospital. “A new Tampa General location in Ybor will ensure that patients don’t have to sacrifice quality for convenience. They can access world-class care where they live, work and visit.” 

This announcement comes on the heels of Tampa General’s opening earlier this month of a 32,000-square-foot innovation center at 1205 East Fifth Avenue, the former Masonite building in Ybor City. The center is home to Tampa General’s innovation team, its venture capital arm TGH Ventures and its analytics and IT teams.

This development in Ybor City is within the Tampa Medical and Research District (TMRD), a robust health care and life sciences ecosystem where leading academic and research health systems, nationally recognized universities, biotechnology companies, and a dynamic network of startups, entrepreneurs, and investors intersect, accelerating the revolution of health care. The TMRD, anchored by TGH and USF Health, is expected to drive significant economic development by attracting companies in health care and life sciences, artificial intelligence, defense and technology.

Tampa General’s plans are in concert with Shaw’s broader vision already underway to revitalize Ybor City. Working with the deep-rooted family businesses and celebrated landmarks of the neighborhood, Shaw is pursuing a plan that puts Ybor back on the map as a premier destination with authentic tributes to its rich culture and vibrant history.

The transformation began with the creation of the Gasworx district, which bridges the gap between Historic Ybor, Downtown’s Channel District and Water Street. Development of Gasworx is in progress, bringing new office space, housing units, infrastructure, sidewalks and multi-use trails to the famous Cigar Capital of the World.