Persistent and Recurrent Hyperparathyroidism | Tampa General Hospital

Persistent and Recurrent Hyperparathyroidism

Persistent and recurrent hyperparathyroidism occurs after a patient has been treated for hyperparathyroidism and still shows higher than normal levels of blood calcium and parathyroid hormone (PTH).

Persistent hyperparathyroidism is a condition when calcium levels and PTH have not stabilized within six months of parathyroid treatment.

Recurrent hyperparathyroidism is defined as elevated calcium levels and PTH that returns at least six to 12 months after proper levels had previously been stabilized. 

What Causes Persistent and Recurrent Hyperparathyroidism?

There are a few factors that can contribute to persistent and recurrent hyperparathyroidism, including:

  • Multiple gland disease (MGD)
  • Ectopic gland location
  • Supernumerary glands
  • Surgeon inexperience
  • Persistent or metastatic parathyroid carcinoma
  • Errors on frozen section biopsies or intraoperative PTH monitoring

What are the Symptoms of Persistent and Recurrent Hyperparathyroidism?

Patients with persistent and recurrent hyperparathyroidism may have symptoms similar to what they experienced before treatment, such as:

  • Abdominal pain (pancreatitis)
  • Brittle bones (osteoporosis or osteopenia)
  • Decreased kidney function
  • Depression
  • Heart disease
  • Increased urination
  • Joint pain
  • Kidney stones
  • Loss of appetite
  • Muscle weakness
  • Nausea or vomiting

However, it is also possible for patients to be asymptomatic. This is just one of the reasons why at Tampa General Hospital’s Parathyroid & Thyroid Institute, we place high importance on post-operative care. Our patients have an open line of communication with our parathyroid surgeons and staff, as well as access to information and fallow-up.

How are Persistent and Recurrent Hyperparathyroidism Diagnosed?

Diagnosing persistent and recurrent hyperparathyroidism consists of regular monitoring of patient’s calcium and PTH levels, in addition to self-monitoring for symptoms by the patient.

How are Persistent and Recurrent Hyperparathyroidism Treated?

Treatment of persistent and recurrent hyperparathyroidism can vary depending on the reason for the elevated calcium and PTH levels. However, reoperative treatment is considered the first line of treatment in most cases.

Become a Patient

Our surgeons, Dr. Douglas Politz and Dr. José Lopez, are two of the most experienced and knowledgeable parathyroid surgeons operating in the world today. They offer patients cure rates close to 100%, minimal complications and world-class post-operative care.