Hyperparathyroidism Symptoms

Hyperparathyroidism symptoms vary from person to person, with many individuals exhibiting mild or no symptoms. Doctors may be able to diagnosis a patient with primary hyperparathyroidism — the most common type of hyperparathyroidism — through regular bloodwork before symptoms begin to show. Primary hyperparathyroidism occurs when issues with one or more of the four parathyroid glands cause them to overproduce parathyroid hormone (PTH). Increased PTH blood levels, in turn, lead to increased blood calcium levels as PTH takes calcium from bone. When readings of these two are elevated together in blood test results, primary hyperparathyroidism is the cause in most cases. Blood phosphorus levels will also be low.

If primary hyperparathyroidism symptoms do develop, they are usually the result of elevated blood calcium levels (hypercalcemia). Milder symptoms include: 

  • Body aches
  • Weakness
  • Depression
  • Fatigue

More severe primary hyperparathyroidism symptoms include the following:

  • Kidney stones
  • Osteoporosis
  • Excessive urination
  • Depression and forgetfulness
  • Confusion
  • Nausea
  • Vomiting
  • Constipation
  • Loss of appetite

The symptoms of secondary hyperparathyroidism may be similar to those of primary hyperparathyroidism, but an individual with this form of the disease will not have elevated blood calcium levels. Secondary hyperparathyroidism develops when another condition lowers calcium levels in the body, causing the parathyroid glands to overproduce PTH in an attempt to elevate calcium levels. Since PTH takes calcium from bone, symptoms will usually include osteoporosis and bone and joint pain.

At Tampa General Hospital’s Parathyroid Center, our physicians have the advanced technology to investigate hyperparathyroidism symptoms and determine if a patient has the disease. We are also the only hospital in the nation that offers minimally invasive radioguided parathyroid (MIRP) surgery to treat hyperparathyroidism, and we've been rated by U.S. News & World Report as one of America's Best Hospitals for Diabetes & Endocrinology.