Pancreas Transplant Selection Criteria

Any adult with the diagnosis of Type I diabetes with Chronic Kidney Disease (CKD), Stage V or End Stage Renal Disease (ESRD), Stage VI, may be considered a candidate for transplantation evaluation. Some CKD, Stage IV patients may also be considered.

Absolute Contraindications to being considered for transplant:

  • Active malignancy (cancer)
  • Positive HIV status
  • Severe cardiac and/or peripheral vascular disease that cannot be corrected.  Severe cardiomyopathy with an Ejection Fraction < 25%.
  • No insurance coverage or ability to handle expenses involved with transplant
  • Inadequate support system (family, friends, etc. to help care for the patient)
  • Documented history of non-compliance with medical regimen and/or medications without reasonable justification
  • Severe pulmonary hypertension that cannot be controlled or treated
  • Patients > 80 years.
  • BMI > 40
  • Uncontrolled or active psychiatric disorders
  • Active substance abuse (drugs, alcohol, etc.)

Relative Contraindications (depends upon particular patient and degree of illness):

  • Active or chronic untreated infections
  • History of malignancy within past 2-5 years
  • Active immunologic disorders potentially impacting the transplanted graft
  • History of significant cardiac and/or peripheral vascular disease with active tobacco use
  • Non-intact urinary tract or no viable diversion
  • BMI between 35 and 40
  • Active Hepatitis B or C
  • Highly sensitized (high antibody level) patients and those patients nonresponsive to treatment