Monoclonal Antibody Infusion

Monoclonal antibody infusion is a promising treatment for COVID-19, as studies have shown that it can help reduce the risk of hospitalization and worsening COVID-19 symptoms. Monoclonal antibodies are similar to antibodies that are produced naturally in the body to respond to an infection, but are artificially produced in a lab and designed to strongly resist the virus by recognizing the spike protein on its outer shell. In doing so, these antibodies interfere with the virus’ ability to multiply within the body, giving the immune system more time to launch a response to the COVID-19 infection. Tampa General Hospital was the first hospital in Florida to offer monoclonal antibody treatment to COVID-19 patients. It is administered in our Global Emerging Diseases Institute (GEDI) outpatient clinic under an emergency use authorization (EUA).

Who Can Receive Monoclonal Antibody Infusion Treatment?

Monoclonal antibody infusion treatment requires a referral and is specifically only for patients who have received a positive COVID-19 test, are within seven days of symptom onset (10 days for immunocompromised patients) and meet one or more of the following high-risk criteria:

  • Pregnant

  • Have severe kidney disease

  • Have solid organ transplant

  • Severe drug interactions with oral antiviral medications such as paxlovid or molnupiravir

  • Children over 12 years of age and weigh at least 88 lbs

How Is Monoclonal Antibody Infusion Treatment Administered?

At TGH, we offer a variety of monoclonal antibodies, depending on availability to treat COVID-19.

The infusion(s) take about an hour and then patients must wait in observation for an hour. As long as you are not experiencing any adverse effects, you’ll be able to go home afterwards. 

How Are Other Covid Treatments Administered?

For those who might not qualify for the monoclonal antibody infusion, Tampa General offers oral treatments, such as paxlovid as another potential option. The supply of this outpatient treatment is dependent on drug availability at the time of the patients’ appointment.

What to Expect

There are certain side effects to be aware of when undergoing this treatment. For example, you may experience bleeding, bruising, soreness, swelling or infection at the infusion site.

Once a referral is submitted, based on the patient's risk profile for progression to severe disease and our availability to treat within the therapy's approved time window, the patient will be contacted to schedule an appointment within 48 hours. Because there are many patients who will not qualify, patients who do not meet criteria or cannot be scheduled within the approved time window will not be contacted.


In studies, monoclonal antibody infusions have shown to reduce hospitalizations and severe illness in patients with COVID-19. This treatment is especially useful for patients with weakened immune systems whose bodies will have a hard time fighting the virus.

Preparing for your appointment

Please arrive 15 minutes early for your appointment. The outpatient infusion clinic is located on the main campus of Tampa General Hospital in the Global Emerging Diseases Institute (GEDI).

Address: 6 Tampa General Cir, Tampa, FL 33606
Directions: As soon as you come across the bridge to Davis Islands, keep left. As you cross the bridge, continue left to the Harborside Pavilion roundabout and keep right at the roundabout. Take the first left immediately after the roundabout facing the water. Follow signs to the GEDI Infusion Clinic. Parking is available in valet spots at the front of the building or in the adjacent garage.

If you have questions, please email the GEDI clinic.